IDH1 Inhibitor 1 Catalog No.:M24963-C OC(=O)C[C@@H](NC(=O)C1=CC(=CS1)C1C=CC(=CC=1)C1C=CN=CC=1)C1C=CC=CC=1

OC(=O)C[C@@H](NC(=O)C1=CC(=CS1)C1C=CC(=CC=1)C1C=CN=CC=1)C1C=CC=CC=1

with an IC50 of 65 pM

Smiles: COCCOCCOCCS(=O)(=O)CCOCCOCCOCCC(=O)OC(C)(C)C

18-dihydroxy-19

IDH1 Inhibitor 1 Catalog No.:M24963-C OC(=O)C[C@@H](NC(=O)C1=CC(=CS1)C1C=CC(=CC=1)C1C=CN=CC=1)C1C=CC=CC=1IDH1 Inhibitor 1 is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 inhibitor with IC50s of 0. 021 M, 0. 045 M, and 2. 52 M for IDH1R132H, IDH1R132C, and IDH1WT, respectively. Anticancer activity. Product information CAS Number: 2234285 81 3 Molecular Weight: 450. 39 Formula: C20H18F4N6O2 Chemical Name: (4R) 4 (fluoromethyl) 3 (2 {[(1S) 1 {1 [4 (trifluoromethyl)phenyl] 1H imidazol 4 yl}ethyl]amino}pyrimidin 4 yl) 1,3